Fri Mar 18 2022

85 articles - From Saturday Mar 12 2022 to Friday Mar 18 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Ann Intern Med

A Reporting Tool for Adapted Guidelines in Health Care: The RIGHT-Ad@pt Checklist.

The RIGHT-Ad@pt checklist has been developed to improve the reporting of adapted guidelines, focusing on the standardization, rigor, and transparency of the process and the clarity and explicitness of adapted recommendations. Primary funding source None.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Comparison of Patients Infected With Delta Versus Omicron COVID-19 Variants Presenting to Paris Emergency Departments : A Retrospective Cohort Study.

Compared with the Delta variant, infection with the Omicron variant in patients in the ED had different clinical and biological patterns and was associated with better in-hospital outcomes, including higher survival. Primary funding source None.

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Comparison of SARS-CoV-2 Reverse Transcriptase Polymerase Chain Reaction and BinaxNOW Rapid Antigen Tests at a Community Site During an Omicron Surge : A Cross-Sectional Study.

BinaxNOW detected persons with high SARS-CoV-2 levels during the Omicron surge, enabling rapid responses to positive test results. Cheek or throat swabs should not replace nasal swabs. As currently recommended, high-risk persons with an initial negative BinaxNOW result should have repeated testing. Primary funding source University of California, San Francisco.

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Effects of State Opioid Prescribing Laws on Use of Opioid and Other Pain Treatments Among Commercially Insured U.S. Adults.

This study did not identify changes in opioid prescribing or nonopioid pain treatment attributable to state laws. Primary funding source National Institute on Drug Abuse.

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Lancet

Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020-21.

Strengthening death registration systems around the world, long understood to be crucial to global public health strategy, is necessary for improved monitoring of this pandemic and future pandemics. In addition, further research is warranted to help distinguish the proportion of excess mortality that was directly caused by SARS-CoV-2 infection and the changes in causes of death as an indirect consequence of the pandemic. Funding Bill & Melinda Gates Foundation, J Stanton, T Gillespie, and J and E Nordstrom.

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Progress in health among regions of Ethiopia, 1990-2019: a subnational country analysis for the Global Burden of Disease Study 2019.

However, the progress, measured in SDI, life expectancy, TFR, premature mortality, disability, and risk factors, was not uniform. Federal and regional health policy makers should match strategies, resources, and interventions to disease burden and risk factors across regions and cities to achieve national and regional plans, Sustainable Development Goals, and universal health coverage targets. Funding Bill & Melinda Gates Foundation.

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Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy (HOPE-2): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

Various measures of cardiac function and structure were also improved in the CAP-1002 group compared with the placebo group. Longer-term extension studies are needed to confirm the therapeutic durability and safety of CAP-1002 beyond 12 months for the treatment of skeletal myopathy and cardiomyopathy in Duchenne muscular dystrophy. Funding Capricor Therapeutics.

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Transmission of SARS-CoV-2 delta variant (AY.127) from pet hamsters to humans, leading to onward human-to-human transmission: a case study.

This incident also led to onward human transmission. Importation of SARS-CoV-2-infected hamsters was a likely source of this outbreak. Funding US National Institutes of Health, Research Grants Council of Hong Kong, Food and Health Bureau, and InnoHK.

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N Engl J Med

Inhibition of Prekallikrein for Hereditary Angioedema.

Among patients with hereditary angioedema, donidalorsen treatment resulted in a significantly lower rate of angioedema attacks than placebo in this small, phase 2 trial. (Funded by Ionis Pharmaceuticals; ISIS 721744-CS2 ClinicalTrials.gov number, NCT04030598.).

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Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus.

In this 24-week, phase 2 trial involving patients with SLE, iberdomide at a dose of 0.45 mg resulted in a higher percentage of patients with an SRI-4 response than did placebo. Data from larger, longer trials are needed to determine the efficacy and safety of iberdomide in SLE. (Funded by Bristol Myers Squibb; ClinicalTrials.gov number, NCT03161483; EudraCT number, 2016-004574-17.).

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Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A.

In patients with severe hemophilia A, valoctocogene roxaparvovec treatment provided endogenous factor VIII production and significantly reduced bleeding and factor VIII concentrate use relative to factor VIII prophylaxis. (Funded by BioMarin Pharmaceutical; GENEr8-1 ClinicalTrials.gov number, NCT03370913.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

Drug therapy for osteoporosis in older adults.

Head-to-head studies suggest that anabolic agents have greater anti-fracture efficacy and produce larger increases in bone density than anti-resorptive drugs. The effects of anabolic agents are transient, so transition to anti-resorptive drugs is required. The optimal strategy for cycling anabolics, anti-resorptives, and off-treatment periods remains to be determined.

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Offline: The fearful emptiness of power.

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Ukraine's humanitarian disaster: priorities for health.

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N Engl J Med

A New IMiD for Systemic Lupus Erythematosus - Tempering Our Excitement.

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An Antisense Oligonucleotide for Hereditary Angioedema.

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Audio Interview: Can We Make More Effective Covid-19 Vaccines?

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Cryptogenic Organizing Pneumonia.

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Prepare the Way for Hemophilia A Gene Therapy.

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Letters&Replies

Letters to the editors and authors’ replies

Ann Intern Med

The Evidence Behind Robot-Assisted Abdominopelvic Surgery.

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Lancet

Disparity in the selection of patients in clinical trials.

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Midwives need a useable past to shape their future.

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N Engl J Med

AQP1 Promoter Variant, Water Transport, and Outcome in Peritoneal Dialysis.

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AQP1 Promoter Variant, Water Transport, and Outcome in Peritoneal Dialysis.

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AQP1 Promoter Variant, Water Transport, and Outcome in Peritoneal Dialysis. Reply.

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Early Treatment with Sotrovimab for Covid-19.

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Early Treatment with Sotrovimab for Covid-19.

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Early Treatment with Sotrovimab for Covid-19.

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Early Treatment with Sotrovimab for Covid-19. Reply.

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Efficacy of a Fourth Dose of Covid-19 mRNA Vaccine against Omicron.

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Four-Month Rifapentine Regimens for Tuberculosis.

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Four-Month Rifapentine Regimens for Tuberculosis. Reply.

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Human Infection with an Avian-Origin Influenza A (H10N3) Virus.

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Molnupiravir for Covid-19 in Nonhospitalized Patients.

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Molnupiravir for Covid-19 in Nonhospitalized Patients.

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Molnupiravir for Covid-19 in Nonhospitalized Patients.

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Molnupiravir for Covid-19 in Nonhospitalized Patients.

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Molnupiravir for Covid-19 in Nonhospitalized Patients. Reply.

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Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants.

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Snake Envenomation.

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Snake Envenomation.

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Snake Envenomation. Reply.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

Annals for Educators - March 2022.

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Annals for Hospitalists - March 2022.

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Challenging the Myths of the Against Medical Advice Discharge.

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Challenging the Myths of the Against Medical Advice Discharge.

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Challenging the Myths of the Against Medical Advice Discharge.

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Challenging the Myths of the Against Medical Advice Discharge.

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Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis.

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Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis.

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Does Stopping Aspirin Differ Fundamentally From Not Starting Aspirin in the Primary Prevention of Cardiovascular Disease Among Older Adults?

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Lifting the Illusion.

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Moving Beyond Race-Based Medicine.

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Moving Beyond Race-Based Medicine.

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Moving Beyond Race-Based Medicine.

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Safety of Ceasing Aspirin Used Without a Clinical Indication After Age 70 Years: A Subgroup Analysis of the ASPREE Randomized Trial.

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Summary for Patients: Comparison of Patients Infected With Delta Versus Omicron COVID-19 Variants Presenting to Paris Emergency Departments.

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Summary for Patients: PCR Testing Versus Rapid Antigen Testing at a Community Site During a COVID-19 Omicron Surge.

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The Shooting.

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Treading Water.

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Web Exclusive. Annals Consult Guys - Timing Elective Surgery in a Patient With Positive Results on a Preadmission Test for SARS-CoV-2.

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Web Exclusive. Annals for Hospitalists Inpatient Notes - Clinical Pearls-Acute Pain Episodes in Sickle Cell Disease.

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Web Exclusive. Annals On Call - Are Adrenal Incidentalomas Clinically Important?

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What you will not know about this body is that.

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Lancet

11 years of war in Syria.

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A girl with unruly locks: molecular genetics makes a diagnosis of uncombable hair syndrome.

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Cell therapy for patients with Duchenne muscular dystrophy.

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Children's health caught up in Ukraine conflict.

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Conflict in Ukraine undermines an already challenged health system.

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Jenna Lester: advancing diversity in dermatology.

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Jeremiah Stamler.

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Meeting the health challenges of displaced populations from Ukraine.

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Reflexivity, Cultural Safety, and improving the health of racially minoritised communities.

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Report finds no common cause for mystery brain disease.

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Spreading of SARS-CoV-2 from hamsters to humans.

Pubmed   Journal   ReadQx   PMC

Successes and challenges to ensure health and wellbeing in Ethiopia.

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The beauty of medical language.

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UK Public Health Science 2022: a call for abstracts.

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N Engl J Med

A Malaria Vaccine for Africa - An Important Step in a Century-Long Quest.

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Case 8-2022: A 54-Year-Old Woman with Episodes of Swelling.

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Malignant Syphilis.

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Pneumatosis Intestinalis in Necrotizing Enterocolitis.

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The Patient Resident.

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What's in a Number? Breaking Down the Residency Match Rate.

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Where Americans Die - Is There Really "No Place Like Home"?

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